Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.125 | 1 | 0.5 | |
Schistosoma mansoni | tyrosinase precursor | 0.125 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.125 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.125 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.125 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.125 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.125 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.125 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.125 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.125 | 1 | 1 |
Onchocerca volvulus | 0.125 | 1 | 0.5 | |
Schistosoma mansoni | tyrosinase precursor | 0.125 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0 | 0.5 |
Onchocerca volvulus | 0.125 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.125 | 1 | 1 |
Onchocerca volvulus | 0.125 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.125 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kinact (binding) | = 0.58 /mM/min | Inhibition of human recombinant AChE after 6 mins by Ellman assay | ChEMBL. | 22738634 |
Kinact (binding) | = 125 /mM/min | Inhibition of Anopheles gambiae AChE expressed in Escherichia coli after 6 mins by Ellman assay | ChEMBL. | 22738634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.