Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0143 | 0.088 | 0.088 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0468 | 0.6319 | 0.6319 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.011 | 0.0322 | 0.0411 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0293 | 0.3382 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0091 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.3382 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0272 | 0.3042 | 0.3335 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0279 | 0.3157 | 0.3157 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0255 | 0.0255 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.1063 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0688 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0506 | 0.6958 | 0.8878 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0559 | 0.7838 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0279 | 0.3157 | 0.3157 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0468 | 0.6319 | 0.6319 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0143 | 0.088 | 0.088 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0169 | 0.1316 | 0.1679 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0143 | 0.088 | 0.1122 |
Schistosoma mansoni | tyrosine kinase | 0.0275 | 0.309 | 0.3388 |
Loa Loa (eye worm) | glutamate receptor | 0.022 | 0.2162 | 0.2162 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0279 | 0.3157 | 0.3157 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0468 | 0.6319 | 0.6929 |
Loa Loa (eye worm) | glutamate receptor | 0.0559 | 0.7838 | 0.7838 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0091 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0635 | 0.912 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.1063 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.011 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.088 | 0.088 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0272 | 0.3042 | 0.3881 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.3382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0688 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0293 | 0.3382 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 625 uM | In vitro binding affinity towards alpha-chymotrypsin from bovine pancreas. | ChEMBL. | 3806568 |
Ki (binding) | = 625 uM | In vitro binding affinity towards alpha-chymotrypsin from bovine pancreas. | ChEMBL. | 3806568 |
kinact (binding) | = 0.0912 min-1 | Maximum rate of inactivation towards alpha-chymotrypsin calculated as the inactivation rate constant (Kinact) | ChEMBL. | 3806568 |
kinact (binding) | = 0.0912 min-1 | Maximum rate of inactivation towards alpha-chymotrypsin calculated as the inactivation rate constant (Kinact) | ChEMBL. | 3806568 |
T1/2 (ADMET) | = 7.6 min | half-life period calculated by using rate of inactivation. | ChEMBL. | 3806568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.