Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | complement component 3a receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | ATP-dependent RNA helicase | 0.0694 | 0.5 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0694 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0694 | 0.5 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0694 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0694 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0694 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0694 | 0.5 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0694 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0694 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0694 | 0.5 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0694 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0694 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0694 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0694 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0694 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0694 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0694 | 0.5 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0694 | 0.5 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0694 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0694 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0694 | 0.5 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0694 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human C5a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant up to 1 uM by degranulation assay | ChEMBL. | 22500977 | |
Activity (functional) | Antagonist activity at human C5a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant up to 1 uM compound preincubated for 10 mins by degranulation assay | ChEMBL. | 22500977 | |
Activity (functional) | = 42 % | Antagonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as inhibition of FLPLAR-induced beta-hexosaminidase activity in cell supernatant measuring minimum receptor activity compound preincubated for 10 mins by degranulation assay | ChEMBL. | 22500977 |
Activity (functional) | = 42 % | Antagonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as inhibition of human recombinant C3a -induced beta-hexosaminidase activity in cell supernatant measuring minimum receptor activity compound preincubated for 10 mins by degranulation assay | ChEMBL. | 22500977 |
EC50 (functional) | = 6 | Agonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant by degranulation assay | ChEMBL. | 22500977 |
Emax (functional) | = 29 % | Agonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant by degranulation assay relative to recombinant human C3a | ChEMBL. | 22500977 |
Emax (functional) | = 29 % | Agonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant by degranulation assay relative to FLPLAR | ChEMBL. | 22500977 |
IC50 (functional) | = 7.63 | Antagonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant compound preincubated for 10 mins by degranulation assay | ChEMBL. | 22500977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.