Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 0.09 % | Positive allosteric activity at GPR109A in human HEK cells assessed as shift in EC50 of nicotinic acid at 10 uM pretreated for 30 mins measured after 90 mins by [35S]-GTPgammaS binding assay | ChEMBL. | 22420767 |
Emax (functional) | = 15 % | Positive allosteric activity at GPR109A in human HEK cells at 1 uM pretreated for 30 mins measured after 90 mins by [35S]-GTPgammaS binding assay | ChEMBL. | 22420767 |
Emax (functional) | = 27 % | Positive allosteric activity at GPR109A in human HEK cells at 3 uM pretreated for 30 mins measured after 90 mins by [35S]-GTPgammaS binding assay | ChEMBL. | 22420767 |
Emax (functional) | = 50 % | Positive allosteric activity at GPR109A in human HEK cells at 10 uM pretreated for 30 mins measured after 90 mins by [35S]-GTPgammaS binding assay | ChEMBL. | 22420767 |
Emax (functional) | = 111 % | Positive allosteric activity at GPR109A in human HEK cells assessed as shift in EC50 of nicotinic acid at 1 uM pretreated for 30 mins measured after 90 mins by [35S]-GTPgammaS binding assay | ChEMBL. | 22420767 |
Emax (functional) | = 123 % | Positive allosteric activity at GPR109A in human HEK cells assessed as shift in EC50 of nicotinic acid at 3 uM pretreated for 30 mins measured after 90 mins by [35S]-GTPgammaS binding assay | ChEMBL. | 22420767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.