Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, KQT-like subfamily, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1154 | 0.1178 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3271 | 0.334 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0078 | 0.3271 | 0.334 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1154 | 0.1154 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1154 | 0.1154 |
Onchocerca volvulus | 0.0104 | 0.507 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1154 | 0.1154 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0174 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1154 | 0.1154 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0104 | 0.507 | 0.507 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0171 | 0.9794 | 1 |
Onchocerca volvulus | 0.0104 | 0.507 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.404 | 0.4126 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1154 | 0.1154 |
Onchocerca volvulus | 0.0104 | 0.507 | 1 | |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.0078 | 0.3271 | 0.3271 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.507 | 0.5177 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1154 | 0.1154 |
Brugia malayi | Cation transporter family protein | 0.0104 | 0.507 | 0.507 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1154 | 0.1154 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1154 | 0.1154 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0104 | 0.507 | 0.507 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.507 | 0.5177 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0078 | 0.3271 | 0.3271 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3271 | 0.334 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.7 uM | Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction by liquid scintillation counting | ChEMBL. | 24900334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.