Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | phospholipase D | 0.0169 | 0.8562 | 0.8562 |
Trypanosoma brucei | cardiolipin synthetase | 0.0067 | 0.1973 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0067 | 0.1973 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.0192 | 1 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0067 | 0.1973 | 0.1973 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.8027 | 1 |
Echinococcus multilocularis | phospholipase D1 | 0.0192 | 1 | 1 |
Echinococcus multilocularis | phospholipase D | 0.0169 | 0.8562 | 0.8562 |
Echinococcus granulosus | phospholipase D1 | 0.0192 | 1 | 1 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0067 | 0.1973 | 0.5 |
Onchocerca volvulus | Putative phospholipase D | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.5702 | 0.7103 |
Entamoeba histolytica | phospholipase D, putative | 0.0192 | 1 | 1 |
Schistosoma mansoni | phospholipase D | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.5702 | 0.7103 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.8027 | 1 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0067 | 0.1973 | 0.5 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0067 | 0.1973 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 30 % | Inhibition of protein synthesis in Escherichia coli S30 extract at 2 uM after 75 mins by luciferase based luminescence assay relative to GE2270A | ChEMBL. | 22315981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.