Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | phospholipase D superfamily protein | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase | 0.0106 | 0.2246 | 1 |
Plasmodium vivax | phosphatidylglycerophosphate synthase, putative | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | phospholipase D | 0.0269 | 0.8611 | 0.8562 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0106 | 0.2246 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.034 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.5848 | 0.7225 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | phospholipase D | 0.0269 | 0.8611 | 0.8562 |
Entamoeba histolytica | phospholipase D, putative | 0.0304 | 1 | 1 |
Onchocerca volvulus | Putative phospholipase D | 0.0057 | 0.034 | 0.5 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.8094 | 1 |
Plasmodium vivax | cardiolipin synthetase, putative | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0106 | 0.2246 | 0.5 |
Echinococcus granulosus | phospholipase D1 | 0.0304 | 1 | 1 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0057 | 0.034 | 1 |
Plasmodium falciparum | mitochondrial cardiolipin synthase, putative | 0.0049 | 0 | 0.5 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0106 | 0.2246 | 0.5 |
Plasmodium falciparum | phosphatidylglycerophosphate synthase | 0.0049 | 0 | 0.5 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0057 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.8094 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0106 | 0.2246 | 0.2246 |
Loa Loa (eye worm) | phospholipase D | 0.0057 | 0.034 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.5848 | 0.7225 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0106 | 0.2246 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0304 | 1 | 1 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | phospholipase D1 | 0.0304 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | cardiolipin synthase | 0.0049 | 0 | 0.5 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0049 | 0 | 0.5 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | phospholipase D | 0.0304 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.