Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 35 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.8094 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0099 | 1 | 1 |
Echinococcus granulosus | phospholipase D1 | 0.0099 | 1 | 1 |
Echinococcus multilocularis | phospholipase D | 0.0087 | 0.8611 | 0.8562 |
Trypanosoma brucei | cardiolipin synthetase | 0.0035 | 0.2246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.8094 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0035 | 0.2246 | 0.5 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0035 | 0.2246 | 0.2246 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | phospholipase D | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.5848 | 0.7225 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | phospholipase D | 0.0019 | 0.034 | 0.042 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.0099 | 1 | 1 |
Echinococcus multilocularis | phospholipase D1 | 0.0099 | 1 | 1 |
Plasmodium falciparum | mitochondrial cardiolipin synthase, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0019 | 0.034 | 0.034 |
Onchocerca volvulus | Putative phospholipase D | 0.0019 | 0.034 | 0.5 |
Plasmodium vivax | phosphatidylglycerophosphate synthase, putative | 0.0016 | 0 | 0.5 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0019 | 0.034 | 1 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.5848 | 0.7225 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.034 | 0.042 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0035 | 0.2246 | 0.5 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.0016 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cardiolipin synthase | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | phospholipase D | 0.0087 | 0.8611 | 0.8562 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0035 | 0.2246 | 0.5 |
Plasmodium vivax | cardiolipin synthetase, putative | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | phosphatidylglycerophosphate synthase | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0035 | 0.2246 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 9.78 uM | Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay | ChEMBL. | 22572579 |
EC50 (functional) | = 340 uM | Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation after 5 hrs by Tango assay | ChEMBL. | 22572579 |
Efficacy (functional) | = 64 % | Agonist activity at GPR35 in human U2OS cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation after 5 hrs by Tango assay relative to zaprinast | ChEMBL. | 22572579 |
Efficacy (functional) | = 159 % | Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay relative to zaprinast | ChEMBL. | 22572579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.