Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0376 | 1 | 0.5 |
Onchocerca volvulus | 0.0376 | 1 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0376 | 1 | 0.5 |
Onchocerca volvulus | 0.0376 | 1 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0376 | 1 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Echinococcus granulosus | Mastin | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0376 | 1 | 0.5 |
Onchocerca volvulus | 0.0376 | 1 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Onchocerca volvulus | 0.0376 | 1 | 0.5 | |
Echinococcus multilocularis | enteropeptidase | 0.0376 | 1 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0376 | 1 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117601 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0376 | 1 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0376 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0376 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117601 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0376 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117601 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0376 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Echinococcus multilocularis | Mastin | 0.0376 | 1 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0376 | 1 | 0.5 |
Onchocerca volvulus | 0.0376 | 1 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0376 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0376 | 1 | 0.5 |
Onchocerca volvulus | 0.0376 | 1 | 0.5 | |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0376 | 1 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0376 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0376 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0117601 | 0.5 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0376 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0376 | 1 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0376 | 1 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0376 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.4 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in O-positive human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by scintillation counting in presence of BSA | ChEMBL. | 24900369 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 24900369 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.