Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | prolyl endopeptidase | 0.0382 | 1 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0382 | 1 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0382 | 1 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0382 | 1 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0382 | 1 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0382 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0342 | 0.8259 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0382 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0152 | 0 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0382 | 1 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0152 | 0 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 33.37 uM | Inhibition of human recombinant PDE7A1-mediated [3H]cAMP hydrolysis after 20 mins by scintillation proximity assay | ChEMBL. | 22385507 |
Inhibition (binding) | = 49.5 % | Inhibition of human recombinant PDE7A1-mediated [3H]cAMP hydrolysis at 10 uM after 20 mins by scintillation proximity assay | ChEMBL. | 22385507 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.