Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0081 | 0.1252 | 0.1252 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0051 | 0.0408 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1252 | 0.1252 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0264 | 0.647 | 0.6412 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0153 | 0.3326 | 0.3439 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0051 | 0.0408 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0358 | 0.9156 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0153 | 0.3326 | 0.4077 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0051 | 0.0408 | 0.032 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0285 | 0.7082 | 0.8914 |
Loa Loa (eye worm) | glutamate receptor | 0.0124 | 0.2482 | 0.2482 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0388 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0315 | 0.7926 | 1 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0051 | 0.0408 | 0.0253 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0264 | 0.647 | 0.6976 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.008 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0315 | 0.7926 | 0.7926 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0081 | 0.1252 | 0.1252 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0051 | 0.0408 | 0.0253 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.016 | 0.016 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0081 | 0.1252 | 0.1407 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0408 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0408 | 0.0408 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0264 | 0.647 | 0.6412 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | < 10 % | Growth inhibition of human MDA-MB-468 cells at 10 uM after 48 hrs by coulter counter analysis | ChEMBL. | 22743242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.