Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transglutaminase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0043 | 0.4257 | 0.5 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0043 | 0.4257 | 0.5 |
Echinococcus multilocularis | Transglutaminase | 0.0043 | 0.4257 | 0.5 |
Echinococcus granulosus | Transglutaminase | 0.0043 | 0.4257 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Brugia malayi | Thioredoxin family protein | 0.0043 | 0.4257 | 0.4257 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0043 | 0.4257 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0043 | 0.4257 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0043 | 0.4257 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.4257 | 0.5 |
Mycobacterium tuberculosis | Long conserved protein | 0.0043 | 0.4257 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.4257 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0043 | 0.4257 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0043 | 0.4257 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.4257 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0043 | 0.4257 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.4257 | 0.5 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0043 | 0.4257 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.4257 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 1 | 1 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0043 | 0.4257 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.67 uM | Inhibition of human recombinant TG2 by fluorescent transamidation assay | ChEMBL. | 22224594 |
Inhibition (binding) | < 15 % | Inhibition of West Nile virus NS2B-NS3 protease at 50 uM | ChEMBL. | 25148591 |
Inhibition (binding) | < 15 % | Inhibition of Dengue virus serotype 2 NS2B-NS3 protease at 50 uM | ChEMBL. | 25148591 |
Inhibition (binding) | < 15 % | Inhibition of Bovine thrombin using Boc-Val-Pro-Arg-AMC as substrate compound preincubated at 25 uM for 15 mins by fluorescence assay | ChEMBL. | 25148591 |
Inhibition (binding) | < 15 % | Inhibition of human MetAP at 25 uM after 20 mins by HPLC analysis | ChEMBL. | 25148591 |
Ratio (binding) | = 453 | Irreversible inhibition of human recombinant TG2 assessed as ratio of Kinact to Ki | ChEMBL. | 22224594 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.