Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0085 | 0.2026 | 0.2026 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0234 | 1 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0085 | 0.2026 | 0.2026 |
Echinococcus multilocularis | cathepsin b | 0.0145 | 0.5217 | 0.5217 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0085 | 0.2026 | 0.2026 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0085 | 0.2026 | 0.2026 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0056 | 0.045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.3907 | 0.3907 |
Echinococcus multilocularis | nAChR subunit | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | cathepsin b | 0.0145 | 0.5217 | 0.5217 |
Plasmodium vivax | vivapain-2 | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | nAChR subunit | 0.0085 | 0.2026 | 0.3369 |
Brugia malayi | Cation transporter family protein | 0.0085 | 0.2026 | 0.2026 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Onchocerca volvulus | 0.016 | 0.6013 | 0.6013 | |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Onchocerca volvulus | 0.0085 | 0.2026 | 0.2026 | |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0085 | 0.2026 | 0.2026 |
Giardia lamblia | Cathepsin B precursor | 0.0056 | 0.045 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0085 | 0.2026 | 0.2026 |
Giardia lamblia | Cathepsin B precursor | 0.0056 | 0.045 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.016 | 0.6013 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0145 | 0.5217 | 0.8677 |
Toxoplasma gondii | cathepsin B | 0.0056 | 0.045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0085 | 0.2026 | 0.2026 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0085 | 0.2026 | 0.2026 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0145 | 0.5217 | 0.5217 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0234 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0234 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0234 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0234 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0234 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0145 | 0.5217 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0234 | 1 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | nAChR subunit | 0.0085 | 0.2026 | 0.3369 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 0.5217 | 0.8677 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.6013 | 0.6013 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0047 | 0 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0085 | 0.2026 | 0.3369 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0085 | 0.2026 | 0.2026 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0056 | 0.045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0085 | 0.2026 | 0.2026 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0085 | 0.2026 | 0.2026 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0085 | 0.2026 | 0.2026 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0085 | 0.2026 | 0.2026 |
Onchocerca volvulus | Putative nachr subunit | 0.0234 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0085 | 0.2026 | 0.3369 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | LGC-31 protein | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | nAChR subunit | 0.0085 | 0.2026 | 0.3369 |
Onchocerca volvulus | 0.016 | 0.6013 | 0.6013 | |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | ACC-1 protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | nAChR subunit | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Brugia malayi | Cation transporter family protein | 0.016 | 0.6013 | 0.6013 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 0.5217 | 0.8677 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0056 | 0.045 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | cathepsin b | 0.0145 | 0.5217 | 0.5217 |
Onchocerca volvulus | 0.0085 | 0.2026 | 0.2026 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0085 | 0.2026 | 0.2026 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0056 | 0.045 | 0.0748 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5217 | 0.5217 |
Onchocerca volvulus | 0.016 | 0.6013 | 0.6013 | |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | nAChR subunit | 0.0085 | 0.2026 | 0.3369 |
Loa Loa (eye worm) | cathepsin B | 0.0056 | 0.045 | 0.045 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0085 | 0.2026 | 0.3369 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.6013 | 0.6013 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0085 | 0.2026 | 0.2026 |
Onchocerca volvulus | 0.0085 | 0.2026 | 0.2026 | |
Giardia lamblia | Cathepsin B precursor | 0.0056 | 0.045 | 0.5 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0085 | 0.2026 | 0.3369 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | nAChR subunit | 0.0085 | 0.2026 | 0.3369 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0085 | 0.2026 | 0.3369 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0056 | 0.045 | 0.0862 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0145 | 0.5217 | 0.8677 |
Plasmodium vivax | vivapain-2 | 0.0047 | 0 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0085 | 0.2026 | 0.2026 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.016 | 0.6013 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0085 | 0.2026 | 0.3369 |
Brugia malayi | Cation transporter family protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Echinococcus multilocularis | cathepsin b | 0.0145 | 0.5217 | 0.5217 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0085 | 0.2026 | 0.2026 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0047 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0085 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2026 | 0.2026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.