Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | serine/threonine protein kinase, putative | 0.0217 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0217 | 1 | 0.5 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0217 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0217 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0217 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0217 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FC (binding) | = 1.2 | Inhibition of P-gp over expressed in human multidrug-resistant KBVIN cells assessed as intracellular accumulation of doxorubicin at 10uM after 3 hrs by fluorescence microplate reader analysis relative to control | ChEMBL. | 22612652 |
IC50 (ADMET) | > 100 uM | Antiproliferative activity against human A549 cells after 72 hrs by SRB assay | ChEMBL. | 22612652 |
Inhibition (binding) | Inhibition of P-gp over expressed in human multidrug-resistant KBVIN cells after 10 mins by calcein AM accumulation assay | ChEMBL. | 22612652 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.