Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.3173 | 0.3173 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0172 | 1 | 1 |
Echinococcus granulosus | caspase 2 | 0.0091 | 0.3173 | 0.2244 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0091 | 0.3173 | 0.2244 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0091 | 0.3173 | 0.3173 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0172 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.1198 | 0.1198 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.1198 | 0.1198 |
Onchocerca volvulus | Deterin homolog | 0.0172 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.1198 | 0.1198 |
Brugia malayi | Cell death protein 3 precursor | 0.0091 | 0.3173 | 0.3173 |
Onchocerca volvulus | 0.0172 | 1 | 1 | |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.3173 | 0.3173 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.1198 | 0.1198 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.3173 | 0.2244 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.1198 | 0.1198 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0172 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.1198 | 0.1198 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0091 | 0.3173 | 0.2244 |
Echinococcus multilocularis | caspase 2 | 0.0091 | 0.3173 | 0.2244 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0091 | 0.3173 | 0.2244 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 84 % | Agonist activity at human A1 receptor expressed in CHO cells assessed as enhancement of R-PIA mediated ERK1/2 phosphorylation at 3 uM after 5 mins by Alpha-Screen assay | ChEMBL. | 22315963 |
Activity (functional) | = 84 % | Agonist activity at human A1 receptor expressed in CHO cells assessed as enhancement of R-PIA mediated ERK1/2 phosphorylation at 10 uM after 5 mins by Alpha-Screen assay | ChEMBL. | 22315963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.