Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0261 | 1 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0053 | 0.0728 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0053 | 0.0728 | 0.0824 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0235 | 0.8839 | 0.8839 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0235 | 0.8839 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0235 | 0.8839 | 0.8839 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus granulosus | enteropeptidase | 0.0053 | 0.0728 | 0.0824 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0235 | 0.8839 | 0.8839 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0235 | 0.8839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Echinococcus multilocularis | enteropeptidase | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Brugia malayi | Trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Echinococcus multilocularis | Mastin | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Brugia malayi | Trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Echinococcus granulosus | Mastin | 0.0053 | 0.0728 | 0.0824 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0824 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0261 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Brugia malayi | Trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0728 | 0.0728 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | trypsin family protein | 0.0053 | 0.0728 | 0.0728 |
Onchocerca volvulus | 0.0053 | 0.0728 | 1 | |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0053 | 0.0728 | 0.0824 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0053 | 0.0728 | 0.0728 |
Mycobacterium ulcerans | hypothetical protein | 0.0053 | 0.0728 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0053 | 0.0728 | 0.0728 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 37 % | Tested in vitro for inhibition of [3H]-spiperone binding to dopamine receptor D2 at the dose of 10 e-5 M | ChEMBL. | 7901417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.