Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0583 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.4195 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3086 | 0.2946 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3086 | 0.2946 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0583 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.0198 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.3086 | 0.7224 |
Echinococcus multilocularis | geminin | 0.0195 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.4195 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0583 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0198 | 0.0471 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0583 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4195 | 0.4079 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.0198 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0583 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3086 | 0.2946 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.0198 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0198 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0583 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.3086 | 0.2946 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.4195 | 0.4079 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0198 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4195 | 0.4079 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.0198 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0583 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.3086 | 0.7355 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0583 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.3086 | 0.2946 |
Brugia malayi | RNA binding protein | 0.0073 | 0.3086 | 0.7355 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.4195 | 0.4079 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.4195 | 0.4079 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.4195 | 0.4079 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.0198 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3086 | 0.2946 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4195 | 0.4079 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0583 | 0.0965 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0198 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.3086 | 0.7355 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0583 | 0.139 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3086 | 0.2946 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.3086 | 0.7224 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0198 | 0.0471 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.3086 | 0.7224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.