Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | polypeptide deformylase (def) | 0.0226 | 0.3208 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0226 | 0.3208 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0086 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0226 | 0.3208 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0226 | 0.3208 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0086 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0226 | 0.3208 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0086 | 0 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0226 | 0.3208 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0226 | 0.3208 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0226 | 0.3208 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0226 | 0.3208 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 103 uM | Inhibition of human BACE1 (43-454 amino acids) expressed in Escherichia coli BL21 using SEVNLDAEFRHDSGYEK-biotinafter 3 hrs by ELISA | ChEMBL. | 22998419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.