Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | fmrfamide receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | neuropeptide receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0084 | 0.7914 | 0.8677 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | g protein coupled receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | somatostatin receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | nmda type glutamate receptor | 0.008 | 0.7455 | 0.8174 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0024 | 0.0076 | 0.0083 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0082 | 0.7642 | 0.8365 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0082 | 0.7642 | 0.8379 |
Echinococcus multilocularis | serotonin receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0024 | 0.0076 | 0.0083 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0082 | 0.7642 | 1 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0093 | 0.9121 | 1 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | orexin receptor type 2 | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0077 | 0.6972 | 0.7644 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0024 | 0.0076 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | somatostatin receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0084 | 0.7914 | 0.8677 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | allatostatin A receptor | 0.0024 | 0.0076 | 0.0083 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0093 | 0.9121 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0093 | 0.9121 | 1 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0093 | 0.9121 | 0.9114 |
Echinococcus multilocularis | sex peptide receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | serotonin receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | neuropeptide receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus multilocularis | g-protein coupled receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus multilocularis | neuropeptide receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | allatostatin A receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0082 | 0.7642 | 0.8379 |
Echinococcus granulosus | sex peptide receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | glutamate receptor NMDA | 0.0077 | 0.6972 | 0.7644 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | g protein coupled receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | g protein coupled receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | serotonin receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | hypothetical protein | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | g protein coupled receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | fmrfamide receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | fmrfamide receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | g protein coupled receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | g-protein coupled receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0024 | 0.0076 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | g protein coupled receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | neuropeptide receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Onchocerca volvulus | 0.0024 | 0.0076 | 0.5 | |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0093 | 0.9121 | 1 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0093 | 0.9121 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.9121 | 1 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0093 | 0.9121 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0076 | 0.0083 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.008 | 0.7455 | 0.8174 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 100 ug/ml measured every 24 hr by BACTEC 460 radiometric assay | ChEMBL. | No reference | |
IC50 (functional) | = 59.8 ug ml-1 | Antiamoebic activity against Entamoeba histolytica | ChEMBL. | No reference |
Inhibition (binding) | = 5 % | Inhibition of horse BChE at 2 mg/ml by Ellman's method | ChEMBL. | 23062825 |
Inhibition (binding) | = 24.87 % | Inhibition of electric eel AChE at 2 mg/ml by Ellman's method | ChEMBL. | 23062825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.