Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.6068 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.6068 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.6068 | 0.6068 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.6068 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.6068 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.6068 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.6068 | 0.5 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.6068 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.6068 | 0.6068 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0017 | 0 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.6068 | 0.6068 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.6068 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0017 | 0 | 0.5 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.6068 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 1 | 1 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.6068 | 0.6068 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Antibacterial activity against Escherichia coli DSM 426 after 36 hrs by disc diffusion method | ChEMBL. | 22882119 | |
IC50 (ADMET) | > 50 uM | Cytotoxicity against human HL60 cells after 24 hrs by MTT assay | ChEMBL. | 22882119 |
Inhibition (binding) | Inhibition of delta8,7-isomerase in human HL60 cells assessed as accumulation of zymostenol at 1 uM after 24 hrs by GC/MS analysis | ChEMBL. | 22882119 | |
Inhibition (binding) | Inhibition of delta8,7-isomerase in human HL60 cells assessed as accumulation of zymostenol at 50 uM after 24 hrs by GC/MS analysis | ChEMBL. | 22882119 | |
Inhibition (binding) | Inhibition of 7-dehydrocholesterol reductase in human HL60 cells assessed as accumulation of 7-dehydrocholesterol at 50 uM after 24 hrs by GC/MS analysis | ChEMBL. | 22882119 | |
Inhibition (binding) | Inhibition of 7-dehydrocholesterol reductase in human HL60 cells assessed as accumulation of 7-dehydrocholesterol at 1 uM after 24 hrs by GC/MS analysis | ChEMBL. | 22882119 | |
MIC (ADMET) | > 20 ug ml-1 | Antimicrobial activity against Saccharomyces cerevisiae DSM 1333 after 48 hrs | ChEMBL. | 22882119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.