Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 11, subfamily B, polypeptide 1 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 17, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 11, subfamily B, polypeptide 2 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Toxoplasma gondii | cytochrome p450 superfamily protein | Get druggable targets OG5_134469 | All targets in OG5_134469 |
Neospora caninum | Os02g0824100 protein, related | Get druggable targets OG5_134469 | All targets in OG5_134469 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 17, subfamily A, polypeptide 1 | 508 aa | 468 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.054 | 0.5437 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.0621 | 0.6391 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0081 | 0 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0081 | 0 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0081 | 0 | 0.5 |
Plasmodium vivax | kinesin-5 | 0.0081 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0081 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0621 | 0.6391 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0081 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 208 nM | Inhibition of human CYP11B2 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging method | ChEMBL. | 22861193 |
IC50 (binding) | = 275 nM | Inhibition of CYP19 in human placental microsomes using [1beta-3H]-androstendione as a substrate | ChEMBL. | 22861193 |
IC50 (binding) | = 4589 nM | Inhibition of human CYP11B1 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging method | ChEMBL. | 22861193 |
IC50 (binding) | > 10000 nM | Inhibition of human CYP17 expressed in Escherichia coli using progesterone as a substrate | ChEMBL. | 22861193 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.