Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0012 | 0.0018 | 0.0023 |
Onchocerca volvulus | 0.0054 | 0.7409 | 0.5 | |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.006 | 0.8515 | 0.8515 |
Echinococcus multilocularis | jun protein | 0.0068 | 1 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.006 | 0.8515 | 0.8515 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.9669 | 1 |
Echinococcus granulosus | jun protein | 0.0068 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0068 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0054 | 0.7409 | 0.7409 |
Echinococcus multilocularis | Ankyrin | 0.0012 | 0.0018 | 0.0018 |
Schistosoma mansoni | jun-related protein | 0.0056 | 0.774 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0068 | 1 | 1 |
Echinococcus granulosus | Ankyrin | 0.0012 | 0.0018 | 0.0018 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Antiplasmodial activity against trophozoite-stage of Plasmodium falciparum 3D7 after 48 hrs by FACS analysis | ChEMBL. | 23035716 | |
IC50 (binding) | = 26.1 uM | Inhibition of Plasmodium falciparum N-myristoyltransferase using [3H]-myristoyl-CoA and GLYVSRLFNRLFQKK(Biotin)-NH2 as substrate after 30 mins scintillation proximity assay | ChEMBL. | 23035716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.