Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 1 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0503 | 0.139 |
Entamoeba histolytica | hypothetical protein | 0.004 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 1 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.362 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0503 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.362 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.362 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.362 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.362 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.362 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.362 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0503 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.362 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 1 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.362 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.362 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.362 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.362 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.362 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0503 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.362 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.362 | 1 |
Onchocerca volvulus | 0.0026 | 0.362 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 1.45 nM/s | Activity at pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells assessed as initial phosphorylation rate at 10 uM measured every 2 mins for 60 mins by Michaelis-Menten constant based ADP Quest assay | ChEMBL. | 23041456 |
Km (binding) | = 144 uM | Activity at pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells measured every 2 mins for 60 mins by Michaelis-Menten constant based ADP Quest assay | ChEMBL. | 23041456 |
Vmax (binding) | = 23.3 nM/s | Activity at pre-activated human GST-His6-tagged IGF-1R expressed in Sf9 cells measured every 2 mins for 60 mins by Michaelis-Menten constant based ADP Quest assay | ChEMBL. | 23041456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.