Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1071 | 0.1071 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0028 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0028 | 0.1071 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0053 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0053 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0028 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0053 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0053 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0053 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0053 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0053 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0053 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0053 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1071 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0053 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0053 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0053 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0053 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0053 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1071 | 0.1071 |
Brugia malayi | steroid hormone receptor | 0.0053 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0053 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0053 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0028 | 0.1071 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0053 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0053 | 1 | 1 |
Onchocerca volvulus | 0.0053 | 1 | 1 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0053 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0053 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0028 | 0.1071 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0053 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0053 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0028 | 0.1071 | 0.1071 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0053 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0053 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0028 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0028 | 0.1071 | 0.1071 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0053 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0053 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | Antimicrobial activity against bloodstream forms of Trypanosoma brucei gambiense Feo at 10 ug/ml after 72 hrs by resazurin assay | ChEMBL. | 23084895 | |
Inhibition (functional) | Antimicrobial activity against bloodstream forms of Trypanosoma brucei gambiense Feo at 1 ug/ml after 72 hrs by resazurin assay | ChEMBL. | 23084895 | |
Inhibition (functional) | < 5 % | Antimicrobial activity against bloodstream forms of Trypanosoma brucei brucei 90-13 at 10 ug/ml after 72 hrs by resazurin assay | ChEMBL. | 23084895 |
Inhibition (functional) | = 18.1 % | Antimicrobial activity against bloodstream forms of Trypanosoma brucei brucei 90-13 at 1 ug/ml after 72 hrs by resazurin assay | ChEMBL. | 23084895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.