Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0627 | 1 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0627 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0627 | 1 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0627 | 1 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0627 | 1 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0161 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0161 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of Candida albicans ATCC 10231 isocitrate lyase by spectrophotometric analysis | ChEMBL. | 23145909 |
LC50 (ADMET) | = 38.5 uM | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 23145909 |
MIC (functional) | > 100 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 35270 after 24 hrs | ChEMBL. | 23145909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.