Detailed information for compound 1694611

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.394 | Formula: C18H24N2O5
  • H donors: 1 H acceptors: 1 LogP: 1.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@@H]1[C@@H](CC[C@@]2([C@H]1/C(=N\OCc1ccccc1)/C)CO2)OC(=O)N
  • InChi: 1S/C18H24N2O5/c1-12(20-24-10-13-6-4-3-5-7-13)15-16(22-2)14(25-17(19)21)8-9-18(15)11-23-18/h3-7,14-16H,8-11H2,1-2H3,(H2,19,21)/b20-12-/t14-,15+,16-,18+/m1/s1
  • InChiKey: QGWIAAHQFJYZGG-WLQAGAIGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens methionyl aminopeptidase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Entamoeba histolytica methionine aminopeptidase, putative Get druggable targets OG5_127231 All targets in OG5_127231
Neospora caninum hypothetical protein Get druggable targets OG5_127231 All targets in OG5_127231
Onchocerca volvulus Methionine aminopeptidase 2 homolog Get druggable targets OG5_127231 All targets in OG5_127231
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania mexicana methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma brucei methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania braziliensis methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Plasmodium vivax methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Echinococcus multilocularis methionyl aminopeptidase 2 Get druggable targets OG5_127231 All targets in OG5_127231
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Plasmodium falciparum methionine aminopeptidase 2 Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania donovani metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma congolense metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Giardia lamblia Methionine aminopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Babesia bovis methionine aminopeptidase, type II family protein Get druggable targets OG5_127231 All targets in OG5_127231
Candida albicans methionine aminopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Cryptosporidium hominis methionine aminopeptidase, type II Get druggable targets OG5_127231 All targets in OG5_127231
Loa Loa (eye worm) initiation factor 2-associated protein Get druggable targets OG5_127231 All targets in OG5_127231
Cryptosporidium parvum methionine aminopeptidase, type II, putative , an1 domain Get druggable targets OG5_127231 All targets in OG5_127231
Brugia malayi initiation factor 2-associated protein. Get druggable targets OG5_127231 All targets in OG5_127231
Plasmodium yoelii methionine aminopeptidase, type II, putative Get druggable targets OG5_127231 All targets in OG5_127231
Echinococcus granulosus methionyl aminopeptidase 2 Get druggable targets OG5_127231 All targets in OG5_127231
Theileria parva methionine aminopeptidase, type II, putative Get druggable targets OG5_127231 All targets in OG5_127231
Schistosoma japonicum ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma brucei gambiense methionine aminopeptidase 2, putative,metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Toxoplasma gondii methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Plasmodium knowlesi methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_127231 All targets in OG5_127231
Candida albicans methionine aminopeptidase Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania major methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
Leishmania infantum methionine aminopeptidase 2, putative Get druggable targets OG5_127231 All targets in OG5_127231
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0058 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Plasmodium falciparum pyruvate kinase 0.0033 0.3621 0.417
Echinococcus granulosus dro:myosuppressin receptor 0.0058 1 1
Brugia malayi hypothetical protein 0.0058 1 1
Schistosoma mansoni hypothetical protein 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus multilocularis methionyl aminopeptidase 2 0.0053 0.8682 0.8682
Schistosoma mansoni pyruvate kinase 0.0033 0.3621 0.3621
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.3621 0.417
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.1118 0.1118
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0058 1 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.3621 0.417
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus neuropeptide receptor 0.0058 1 1
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0053 0.8682 1
Plasmodium falciparum methionine aminopeptidase 2 0.0053 0.8682 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Brugia malayi AKH receptor 0.0058 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0053 0.8682 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.3621 0.3621
Schistosoma mansoni neuropeptide F-like receptor 0.0058 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0058 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0058 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0058 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0058 1 1
Brugia malayi sulfakinin receptor protein 0.0058 1 1
Brugia malayi larval opioid receptor 0.0058 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0058 1 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.3621 0.417
Onchocerca volvulus Neuropeptide F receptor homolog 0.0058 1 1
Schistosoma mansoni opsin-like receptor 0.0058 1 1
Chlamydia trachomatis pyruvate kinase 0.0033 0.3621 0.5
Echinococcus granulosus serotonin receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus g protein coupled receptor 0.0058 1 1
Brugia malayi hypothetical protein 0.0058 1 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.3621 0.3621
Brugia malayi Melatonin receptor type 1A 0.0058 1 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.3621 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0058 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0058 1 1
Brugia malayi putative neuropeptide receptor 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Brugia malayi neuropeptide F receptor 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Echinococcus multilocularis g protein coupled receptor 0.0058 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0058 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0058 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0058 1 1
Brugia malayi G-protein coupled receptor 0.0058 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0058 1 1
Brugia malayi hypothetical protein 0.0058 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.3621 0.3621
Brugia malayi G-protein coupled receptor 0.0058 1 1
Schistosoma mansoni histamine h1 receptor 0.0058 1 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.3621 0.3621
Echinococcus granulosus neuropeptide Y receptor 0.0058 1 1
Echinococcus granulosus neuropeptide s receptor 0.0058 1 1
Brugia malayi hypothetical protein 0.0058 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0058 1 1
Echinococcus granulosus fmrfamide receptor 0.0058 1 1
Schistosoma mansoni neuropeptide receptor 0.0058 1 1
Schistosoma mansoni biogenic amine receptor 0.0058 1 1
Brugia malayi RE15519p 0.0058 1 1
Brugia malayi Serotonin receptor 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Echinococcus granulosus neuropeptide receptor 0.0058 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0058 1 1
Schistosoma mansoni amine GPCR 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Brugia malayi hypothetical protein 0.0058 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 1 1
Schistosoma mansoni neuropeptide receptor 0.0058 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0058 1 1
Echinococcus multilocularis neuropeptide receptor 0.0058 1 1
Schistosoma mansoni hypothetical protein 0.0058 1 1
Brugia malayi GnHR receptor homolog 0.0058 1 1
Schistosoma mansoni amine GPCR 0.0058 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0053 0.8682 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.3621 0.3621
Echinococcus multilocularis somatostatin receptor 0.0058 1 1
Brugia malayi Dopamine receptor protein 1 0.0058 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 1 1
Echinococcus granulosus sex peptide receptor 0.0058 1 1
Echinococcus granulosus pyruvate kinase 0.0033 0.3621 0.3621
Echinococcus multilocularis neuropeptides capa receptor 0.0058 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0058 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0058 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0058 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0053 0.8682 1
Giardia lamblia Methionine aminopeptidase 0.0053 0.8682 1
Echinococcus granulosus tm gpcr rhodopsin 0.0058 1 1
Echinococcus granulosus g protein coupled receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus g-protein coupled receptor 0.0058 1 1
Schistosoma mansoni neuropeptide receptor 0.0058 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0058 1 1
Echinococcus multilocularis g protein coupled receptor 0.0058 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0058 1 1
Echinococcus multilocularis g protein coupled receptor 0.0058 1 1
Brugia malayi hypothetical protein 0.0058 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0058 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0058 1 1
Echinococcus granulosus allatostatin A receptor 0.0058 1 1
Echinococcus multilocularis neuropeptide receptor 0.0058 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Brugia malayi hypothetical protein 0.0058 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 1 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.3621 0.3621
Echinococcus multilocularis serotonin receptor 0.0058 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0053 0.8682 1
Echinococcus multilocularis serotonin receptor 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Schistosoma mansoni myosin xvIII 0.0058 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0058 1 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.3621 0.3621
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0058 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0058 1 1
Schistosoma mansoni biogenic amine receptor 0.0058 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0058 1 1
Brugia malayi G protein-coupled receptor 0.0058 1 1
Brugia malayi neuropeptide F receptor 0.0058 1 1
Leishmania major methionine aminopeptidase 2, putative 0.0053 0.8682 1
Entamoeba histolytica methionine aminopeptidase, putative 0.0053 0.8682 1
Loa Loa (eye worm) neuropeptide F receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus multilocularis sex peptide receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Schistosoma mansoni hypothetical protein 0.0058 1 1
Schistosoma mansoni biogenic amine receptor 0.0058 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0058 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0058 1 1
Mycobacterium ulcerans pyruvate kinase 0.0033 0.3621 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0058 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.3621 0.3621
Schistosoma mansoni neuropeptide receptor 0.0058 1 1
Brugia malayi ORL1-like opioid receptor 0.0058 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0058 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0058 1 1
Loa Loa (eye worm) initiation factor 2-associated protein 0.0053 0.8682 0.8682
Schistosoma mansoni amine GPCR 0.0058 1 1
Brugia malayi Dopamine receptor protein 2 0.0058 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 1 1
Schistosoma mansoni hypothetical protein 0.0058 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 1 1
Echinococcus multilocularis allatostatin A receptor 0.0058 1 1
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0053 0.8682 0.8682
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0058 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0058 1 1
Echinococcus multilocularis fmrfamide receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1118 0.1118
Onchocerca volvulus 0.0058 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0058 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0058 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 1 1
Echinococcus multilocularis orexin receptor type 2 0.0058 1 1
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0053 0.8682 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0053 0.8682 1
Brugia malayi hypothetical protein 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0058 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0058 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 1 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.1878 0.1878
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Brugia malayi Dopamine receptor 0.0058 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0058 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 1 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.3621 0.3621
Schistosoma mansoni pyruvate kinase 0.0033 0.3621 0.3621
Echinococcus multilocularis g-protein coupled receptor 0.0058 1 1
Echinococcus granulosus hypothetical protein 0.0058 1 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.3621 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0058 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus g protein coupled receptor 0.0058 1 1
Brugia malayi initiation factor 2-associated protein. 0.0053 0.8682 0.8682
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus somatostatin receptor 0.0058 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0053 0.8682 1
Brugia malayi Serotonin receptor 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Schistosoma mansoni opsin-like receptor 0.0058 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0058 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0058 1 1
Plasmodium vivax methionine aminopeptidase 2, putative 0.0053 0.8682 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0058 1 1
Brugia malayi hypothetical protein 0.0058 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0058 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0058 1 1
Echinococcus granulosus methionyl aminopeptidase 2 0.0053 0.8682 0.8682
Schistosoma mansoni growth hormone secretagogue receptor 0.0058 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 1 1
Schistosoma mansoni amine GPCR 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0058 1 1
Schistosoma mansoni amine GPCR 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0053 0.8682 1
Schistosoma mansoni adenoreceptor 0.0058 1 1
Onchocerca volvulus 0.0058 1 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.3621 0.417
Leishmania major pyruvate kinase 0.0033 0.3621 0.417
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 1 1
Echinococcus multilocularis fmrfamide receptor 0.0058 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0058 1 1
Leishmania major pyruvate kinase 0.0033 0.3621 0.417
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Brugia malayi follicle stimulating hormone receptor 0.0058 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0058 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0058 1 1
Schistosoma mansoni opsin-like receptor 0.0058 1 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.3621 0.3621
Onchocerca volvulus 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 1 1
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0053 0.8682 0.8682
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0058 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0058 1 1
Echinococcus granulosus orexin receptor type 2 0.0058 1 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.3621 0.3621
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0058 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1
Echinococcus granulosus pyruvate kinase 0.0033 0.3621 0.3621
Brugia malayi putative neuropeptide receptor NPR1 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 57 nM Inhibitory activity against Methionine aminopeptidase 2 ChEMBL. 14684305

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.