Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0443 | 0.5 | 0.5 |
Brugia malayi | Fibroblast growth factor family protein | 0.0443 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | In vivo antitumor activity against HX/62 cell line. | ChEMBL. | 7636864 |
IC50 (functional) | > 50 uM | In vitro antitumor activity against SK-OV-3 cell line. | ChEMBL. | 7636864 |
IC50 (functional) | > 50 uM | In vitro antitumor activity against 41M cell line. | ChEMBL. | 7636864 |
IC50 (functional) | > 50 uM | In vitro antitumor activity against 41McisR cell line. | ChEMBL. | 7636864 |
IC50 (functional) | > 50 uM | In vitro antitumor activity against CH1 cell line. | ChEMBL. | 7636864 |
IC50 (functional) | > 50 uM | In vitro antitumor activity against CH1cisR cell line. | ChEMBL. | 7636864 |
IC50 (functional) | > 50 uM | In vitro antitumor activity against A2780 cell line. | ChEMBL. | 7636864 |
IC50 (functional) | > 50 uM | In vitro antitumor activity against A2780cisR cell line. | ChEMBL. | 7636864 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.