Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0144 | 0.6918 | 0.8736 |
Loa Loa (eye worm) | glutamate receptor | 0.0159 | 0.7809 | 0.7629 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0159 | 0.7809 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0063 | 0.2059 | 0.1406 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0196 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0078 | 0.2951 | 0.3107 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0078 | 0.2951 | 0.3239 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0134 | 0.6271 | 0.6885 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0181 | 0.9109 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.