Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | chitinase/cellulase | 0.0076 | 0 | 0.5 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Brugia malayi | Endochitinase | 0.0099 | 0.3645 | 0.2052 |
Entamoeba histolytica | chitinase, putative | 0.0089 | 0.2004 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0099 | 0.3645 | 0.2052 |
Plasmodium falciparum | conserved protein, unknown function | 0.0141 | 1 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0141 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0141 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0141 | 1 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0099 | 0.3645 | 0.2052 |
Loa Loa (eye worm) | chitinase I | 0.0089 | 0.2004 | 0.2004 |
Leishmania major | chitinase | 0.0089 | 0.2004 | 0.5 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0141 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible chitinase | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0086 | 0.1641 | 0.1641 |
Onchocerca volvulus | Putative endochitinase | 0.0099 | 0.3645 | 0.2052 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0089 | 0.2004 | 0.2004 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Brugia malayi | endochitinase | 0.0099 | 0.3645 | 0.2052 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.