Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0015 | 0.0519 | 0.1028 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.4531 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0019 | 0.1334 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.1334 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0015 | 0.0519 | 0.1028 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.1334 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0031 | 0.3157 | 0.6252 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0015 | 0.0527 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0015 | 0.0527 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3785 | 0.8354 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0015 | 0.0519 | 0.1145 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0019 | 0.1334 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0015 | 0.0527 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.4531 | 0.4531 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0519 | 0.1145 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.3416 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0072 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0031 | 0.3157 | 0.6968 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.3416 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0019 | 0.1334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1334 | 0.2945 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0019 | 0.1334 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0015 | 0.0519 | 0.0519 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.505 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0015 | 0.0519 | 0.0519 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.4531 | 0.4531 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0031 | 0.3157 | 0.3157 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.1334 | 0.2945 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0015 | 0.0527 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Onchocerca volvulus | 0.0019 | 0.1334 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.3157 | 0.6252 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0015 | 0.0519 | 0.0519 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0019 | 0.1334 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0031 | 0.3157 | 0.3157 |
Echinococcus granulosus | voltage gated potassium channel | 0.0015 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0527 | 0.1162 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0019 | 0.1334 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0.1334 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.4531 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0031 | 0.3157 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.1334 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0042 | 0.505 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.