Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fibroblast growth factor family protein | 0.0434 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1737 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1737 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1737 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1737 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1737 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.1737 | 0.5 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Giardia lamblia | Hypothetical protein | 0.0434 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16.8 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 16.8 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 25 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 25 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 25 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 25 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 14 % | Percent inhibition against rat liver Dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 14 % | Percent inhibition against rat liver Dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 15 % | Percentage inhibition against Pneumocystis carinii Dihydrofolate reductase. | ChEMBL. | 9301665 |
Inhibition (binding) | = 15 % | Percentage inhibition against Pneumocystis carinii Dihydrofolate reductase. | ChEMBL. | 9301665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.