Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5667 | 0.5667 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1877 | 0.3312 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5667 | 0.5667 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1877 | 0.3312 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.1877 | 0.1877 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.1877 | 0.1877 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5667 | 0.5667 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.624 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.1877 | 0.3312 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1877 | 0.1877 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1877 | 0.3312 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5667 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5667 | 0.5667 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.1877 | 0.1877 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.1877 | 0.3312 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 1 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5667 | 0.5667 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.624 | 0.624 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.624 | 0.624 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5667 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1877 | 0.3312 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5667 | 0.5667 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.