Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1326 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1326 | 0.121 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1326 | 0.1393 |
Brugia malayi | RNA binding protein | 0.0062 | 0.5051 | 0.4666 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.5051 | 0.4666 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.5051 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0953 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0722 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5706 | 0.5371 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0953 | 0.0463 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.5051 | 0.4666 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0953 | 0.0533 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0953 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0953 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0953 | 0.0249 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0953 | 0.1887 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0953 | 0.0533 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0953 | 0.0249 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1326 | 0.2624 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0953 | 0.0249 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.5051 | 0.4666 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1326 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1326 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0953 | 0.0463 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0953 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0953 | 0.0249 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0953 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1326 | 0.121 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0953 | 0.1887 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.5051 | 0.4666 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.5706 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0953 | 0.0249 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0953 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.5706 | 0.5371 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0722 | 0.143 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0953 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1326 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0953 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.5051 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0953 | 0.0249 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0953 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.5051 | 0.4666 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0953 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0722 | 0.143 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0953 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0953 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1326 | 0.065 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5051 | 0.8686 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0953 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0953 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.