Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.5 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0014 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3 uM | In vitro inhibition of Pt resistant P388 (murine leukaemia) cell growth. | ChEMBL. | 2231598 |
IC50 (functional) | = 3 uM | In vitro inhibition of Pt resistant P388 (murine leukaemia) cell growth. | ChEMBL. | 2231598 |
IC50 (functional) | = 7.3 uM | In vitro inhibition of P388 (murine leukaemia) cell growth. | ChEMBL. | 2231598 |
IC50 (functional) | = 7.3 uM | In vitro inhibition of P388 (murine leukaemia) cell growth. | ChEMBL. | 2231598 |
ILS (functional) | NA 0 % | Increase in mean survival of P388 (murine leukaemia) inoculated mice; no effect. | ChEMBL. | 2231598 |
OD (functional) | = 20 mg kg-1 | Optimal i.p. dose in P388 (murine leukaemia) inoculated mice. | ChEMBL. | 2231598 |
OD (functional) | = 20 mg kg-1 | Optimal i.p. dose in P388 (murine leukaemia) inoculated mice. | ChEMBL. | 2231598 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2231598 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.