Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0123 | 1 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0094 | 0.5667 | 0.5667 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0123 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.5667 | 0.5667 |
Onchocerca volvulus | Deterin homolog | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 1 | 1 |
Echinococcus granulosus | caspase 2 | 0.0094 | 0.5667 | 0.5667 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.5667 | 0.5667 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0094 | 0.5667 | 0.5667 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.5667 | 0.5667 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0123 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 1 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0094 | 0.5667 | 0.5667 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0123 | 1 | 1 |
Onchocerca volvulus | 0.0123 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0123 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0094 | 0.5667 | 0.5667 |
Brugia malayi | hypothetical protein | 0.0094 | 0.5667 | 0.5667 |
Echinococcus multilocularis | caspase 2 | 0.0094 | 0.5667 | 0.5667 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0123 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.