Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1034 | 0.1034 |
Plasmodium vivax | histone deacetylase, putative | 0.0188 | 0.6494 | 0.5159 |
Echinococcus granulosus | histone deacetylase 3 | 0.026 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0188 | 0.6494 | 0.6494 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.026 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0188 | 0.6494 | 0.6494 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0188 | 0.6494 | 0.6494 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.6288 | 0.6288 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0188 | 0.6494 | 0.6494 |
Trypanosoma brucei | histone deacetylase 1 | 0.026 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.026 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.026 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.026 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.026 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.026 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0188 | 0.6494 | 0.5159 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1361 | 0.1361 |
Trypanosoma brucei | histone deacetylase, putative | 0.0188 | 0.6494 | 0.5159 |
Schistosoma mansoni | histone deacetylase | 0.026 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0112 | 0.2758 | 0.2758 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.026 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0042 | 0.0042 |
Brugia malayi | Pre-SET motif family protein | 0.0226 | 0.834 | 0.834 |
Echinococcus granulosus | histone deacetylase 6 | 0.0188 | 0.6494 | 0.6494 |
Leishmania major | histone deacetylase, putative | 0.026 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.026 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0112 | 0.2758 | 0.2758 |
Echinococcus granulosus | histone deacetylase 6 | 0.0188 | 0.6494 | 0.6494 |
Trypanosoma brucei | histone deacetylase 3 | 0.0188 | 0.6494 | 0.5159 |
Trichomonas vaginalis | histone deacetylase, putative | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.2758 | 0.2758 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0188 | 0.6494 | 0.6494 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0188 | 0.6494 | 0.5159 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.026 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.026 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase | 0.0188 | 0.6494 | 0.6494 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.026 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0184 | 0.6288 | 0.6288 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0226 | 0.834 | 0.834 |
Echinococcus granulosus | histone deacetylase 6 | 0.0195 | 0.6821 | 0.6821 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.6288 | 0.6288 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0188 | 0.6494 | 0.5159 |
Brugia malayi | histone deacetylase 11 | 0.0112 | 0.2758 | 0.2758 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0188 | 0.6494 | 0.6494 |
Trichomonas vaginalis | histone deacetylase, putative | 0.026 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.026 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0195 | 0.6821 | 0.6821 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0188 | 0.6494 | 0.5159 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0188 | 0.6494 | 0.6494 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0188 | 0.6494 | 0.5159 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 1 | 1 |
Onchocerca volvulus | 0.0257 | 0.9866 | 1 | |
Brugia malayi | Histone deacetylase 1 | 0.026 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.026 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.026 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0195 | 0.6821 | 0.6821 |
Echinococcus granulosus | histone deacetylase 1 | 0.026 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.026 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0112 | 0.2758 | 0.2758 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0188 | 0.6494 | 0.5159 |
Brugia malayi | Histone deacetylase family protein | 0.0188 | 0.6494 | 0.6494 |
Trichomonas vaginalis | histone deacetylase, putative | 0.026 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0188 | 0.6494 | 0.6494 |
Echinococcus multilocularis | histone deacetylase 1 | 0.026 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0188 | 0.6494 | 0.6494 |
Trichomonas vaginalis | histone deacetylase, putative | 0.026 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.026 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.026 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0112 | 0.2758 | 0.2758 |
Echinococcus granulosus | histone deacetylase 8 | 0.0112 | 0.2758 | 0.2758 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.026 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.026 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0184 | 0.6288 | 0.6288 |
Echinococcus multilocularis | histone deacetylase | 0.0188 | 0.6494 | 0.6494 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.