Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0057 | 0 | 0.5 |
Onchocerca volvulus | 0.0184 | 0.2064 | 0.5 | |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0184 | 0.2064 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0184 | 0.2064 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0344 | 0.467 | 0.2023 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.3263 | 0.1511 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0344 | 0.467 | 0.3284 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0 | 0.5 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 0.9944 | 0.993 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.0672 | 1 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0184 | 0.2064 | 0.5 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0672 | 1 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0344 | 0.467 | 0.2023 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0184 | 0.2064 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0184 | 0.2064 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0184 | 0.2064 | 1 |
Echinococcus multilocularis | transfer RNA-Thr | 0.0672 | 1 | 1 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0672 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.3319 | 0.1581 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0184 | 0.2064 | 0.5 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0127 | 0.1144 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0344 | 0.467 | 0.3284 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.3263 | 0.1511 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0184 | 0.2064 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0344 | 0.467 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0184 | 0.2064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0184 | 0.2064 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.