Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.0798 | 1 |
Plasmodium vivax | phenylalanine--tRNA ligase alpha subunit, putative | 0.0076 | 0.0453 | 0.5 |
Plasmodium falciparum | phenylalanine--tRNA ligase alpha subunit | 0.0076 | 0.0453 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0414 | 0.5192 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit alpha | 0.0361 | 0.3725 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0094 | 0.0663 | 0.0663 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, alpha chain PheS | 0.0361 | 0.3725 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0323 | 0.0323 |
Trypanosoma cruzi | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0076 | 0.0453 | 0.5 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit alpha | 0.0361 | 0.3725 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0327 | 0.3339 | 1 |
Echinococcus multilocularis | phenylalanyl tRNA synthetase alpha chain B | 0.0076 | 0.0453 | 0.0453 |
Schistosoma mansoni | transient receptor potential channel | 0.0097 | 0.07 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Echinococcus granulosus | phenylalanyl tRNA synthetase alpha chain B | 0.0076 | 0.0453 | 0.6476 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0414 | 0.2429 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Trypanosoma brucei | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0076 | 0.0453 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.0798 | 1 |
Leishmania major | phenylalanyl-tRNA synthetase alpha chain, putative | 0.0076 | 0.0453 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0286 | 0.3578 |
Brugia malayi | phenylalanyl (f) trna synthetase protein 1 | 0.0076 | 0.0453 | 0.5681 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0453 | 0.5681 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0094 | 0.0663 | 0.9469 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.2227 | 0.3505 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0097 | 0.07 | 1 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0097 | 0.07 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.0798 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0097 | 0.07 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.07 | 0.8772 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0323 | 0.4609 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0414 | 0.5192 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0323 | 0.4609 |
Toxoplasma gondii | phenylalanyl-tRNA synthetase alpha chain A, putative | 0.0076 | 0.0453 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0327 | 0.3339 | 1 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit alpha | 0.0361 | 0.3725 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0798 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Schistosoma mansoni | phenylalanyl-tRNA synthetase subunit alpha | 0.0076 | 0.0453 | 0.3462 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0327 | 0.3339 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0323 | 0.0323 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.016 | 0.1419 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.