Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0086 | 0.0302 | 0.0302 |
Schistosoma mansoni | nuclear hormone receptor | 0.0086 | 0.0302 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0086 | 0.0302 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0302 | 0.0302 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0086 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0086 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0112 | 0.0112 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0086 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0086 | 0.0302 | 0.0302 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0086 | 0.0302 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0086 | 0.0302 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0302 | 0.0302 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0086 | 0.0302 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1385 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0086 | 0.0302 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0086 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0086 | 0.0302 | 0.0302 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0086 | 0.0302 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0086 | 0.0302 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0086 | 0.0302 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0086 | 0.0302 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0302 | 0.0302 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0086 | 0.0302 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0086 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | nuclear hormone receptor | 0.0086 | 0.0302 | 0.0302 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0086 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0086 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0086 | 0.0302 | 0.0302 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0086 | 0.0302 | 0.0302 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0086 | 0.0302 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0086 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0086 | 0.0302 | 0.0302 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0086 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0086 | 0.0302 | 0.0302 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0086 | 0.0302 | 0.0302 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0086 | 0.0302 | 0.0302 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0086 | 0.0302 | 0.0302 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0112 | 0.0112 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0086 | 0.0302 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0086 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0086 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | nuclear receptor NHR-88 | 0.0086 | 0.0302 | 0.0302 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1385 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0086 | 0.0302 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0086 | 0.0302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0302 | 0.0302 |
Brugia malayi | steroid hormone receptor | 0.0086 | 0.0302 | 0.0302 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0086 | 0.0302 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.