Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | caspase 2 | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.5 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0032 | 0.5 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0032 | 0.5 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0032 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0032 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.