Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | glutaminase, putative | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase 2 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Brugia malayi | glutaminase DH11.1 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Mycobacterium ulcerans | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Schistosoma mansoni | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | potassium channel, putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0036 | 0 | 0.5 |
Leishmania major | ion transport protein-like protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0036 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.5164 | 0.5164 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.5164 | 0.5164 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0569 | 0.936 | 0.936 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0605 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Toxoplasma gondii | ion channel protein | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0036 | 0 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.5164 | 0.5164 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.0605 | 1 | 1 |
Plasmodium vivax | potassium channel, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Plasmodium falciparum | potassium channel | 0.0036 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.5164 | 1 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0036 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0605 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.033 | 0.5164 | 0.5164 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.5164 | 1 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0605 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Plasmodium falciparum | potassium channel | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.0605 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.