TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 580.715 | Formula: C32H44N4O6
H donors: 3 H acceptors: 3 LogP: 4.46 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H](N1C[C@@H](C)[C@H](CN(CC2CCCCC2)C)Oc2c(CC1=O)cc(cc2)NC(=O)Nc1ccc2c(c1)OCO2)C
InChi: 1S/C32H44N4O6/c1-21-16-36(22(2)19-37)31(38)14-24-13-25(33-32(39)34-26-10-12-28-29(15-26)41-20-40-28)9-11-27(24)42-30(21)18-35(3)17-23-7-5-4-6-8-23/h9-13,15,21-23,30,37H,4-8,14,16-20H2,1-3H3,(H2,33,34,39)/t21-,22-,30+/m1/s1
InChiKey: RFZFPTSDEPYSRK-WOGZVKCMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	AKH receptor	0.0171	0.0072	0.0115
Brugia malayi	follicle stimulating hormone receptor	0.0171	0.0072	0.0115
Brugia malayi	sulfakinin receptor protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	neuropeptide s receptor	0.0171	0.0072	0.0072
Schistosoma mansoni	tyrosine kinase	0.0113	0.0014	0.0023
Loa Loa (eye worm)	apoptosis regulator protein	0.1829	0.1703	0.2737
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus granulosus	neuropeptides capa receptor	0.0171	0.0072	0.0072
Brugia malayi	Serotonin receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	amine GPCR	0.0171	0.0072	0.0115
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.1829	0.1703	0.2737
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Entamoeba histolytica	glycylpeptide N-tetradecanoyltransferase, putative	0.6421	0.6222	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0171	0.0072	0.0115
Brugia malayi	Dopamine receptor protein 1	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0171	0.0072	0.0115
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.1829	0.1703	0.1703
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0171	0.0072	0.0072
Schistosoma mansoni	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Brugia malayi	putative neuropeptide receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	tyrosine kinase	0.0113	0.0014	0.0023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0113	0.0014	0.0014
Echinococcus multilocularis	neuropeptides capa receptor	0.0171	0.0072	0.0072
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0171	0.0072	0.0072
Brugia malayi	larval opioid receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0171	0.0072	0.0115
Schistosoma mansoni	tyrosine kinase	0.0112	0.0013	0.0021
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0171	0.0072	0.0115
Echinococcus granulosus	7tm_1 domain containing protein	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	opsin-like receptor	0.0171	0.0072	0.0115
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	somatostatin receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	biogenic amine 5HT receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Brugia malayi	G-protein coupled receptor	0.0171	0.0072	0.0115
Loa Loa (eye worm)	G-protein coupled receptor	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Echinococcus granulosus	sex peptide receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	g-protein coupled receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.1829	0.1703	0.1703
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	growth hormone secretagogue receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	1.0261	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	hypothetical protein	0.1829	0.1703	0.2737
Echinococcus granulosus	hypothetical protein	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	tyrosine kinase	0.0112	0.0013	0.0021
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0171	0.0072	0.0072
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	G-protein coupled receptor	0.0171	0.0072	0.0115
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Brugia malayi	G-protein coupled receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	fmrfamide receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0171	0.0072	0.0072
Echinococcus multilocularis	serotonin receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0171	0.0072	0.0072
Schistosoma mansoni	adenoreceptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Echinococcus granulosus	tm gpcr rhodopsin	0.0171	0.0072	0.0072
Brugia malayi	Serotonin receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0171	0.0072	0.0072
Loa Loa (eye worm)	melatonin receptor type 1A	0.0171	0.0072	0.0115
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0171	0.0072	0.0115
Schistosoma mansoni	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	neuropeptide receptor A26	0.0171	0.0072	0.0072
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	dro:myosuppressin receptor	0.0171	0.0072	0.0072
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Schistosoma mansoni	histamine h1 receptor	0.0171	0.0072	0.0115
Brugia malayi	GnHR receptor homolog	0.0171	0.0072	0.0115
Onchocerca volvulus		0.0291	0.0189	1
Schistosoma mansoni	neuropeptide receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	sex peptide receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	neuropeptide F-like receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	biogenic amine receptor	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Leishmania major	N-myristoyl transferase, putative	0.6421	0.6222	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Brugia malayi	ORL1-like opioid receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	g protein coupled receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	G protein coupled receptor 139	0.0171	0.0072	0.0072
Trypanosoma cruzi	N-myristoyl transferase, putative	0.6421	0.6222	0.5
Schistosoma mansoni	hypothetical protein	0.1829	0.1703	0.2737
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	epidermal growth factor receptor	0.021	0.011	0.011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Brugia malayi	Dopamine receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	neuropeptide f receptor 76f	0.0171	0.0072	0.0115
Schistosoma mansoni	opsin-like receptor	0.0171	0.0072	0.0115
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	orexin receptor type 2	0.0171	0.0072	0.0072
Echinococcus multilocularis	allatostatin A receptor	0.0171	0.0072	0.0072
Brugia malayi	putative neuropeptide receptor NPR1	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	neuropeptide Y receptor	0.0171	0.0072	0.0072
Schistosoma mansoni	hypothetical protein	0.0174	0.0074	0.0119
Echinococcus granulosus	tm gpcr rhodopsin	0.0171	0.0072	0.0072
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Trypanosoma brucei	N-myristoyltransferase	0.6421	0.6222	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0171	0.0072	0.0115
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0171	0.0072	0.0115
Loa Loa (eye worm)	N-myristoyltransferase 2	0.6421	0.6222	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	myosin xvIII	0.0171	0.0072	0.0115
Brugia malayi	neuropeptide F receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	epidermal growth factor receptor	0.0113	0.0014	0.0014
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0171	0.0072	0.0072
Echinococcus granulosus	fmrfamide receptor	0.0171	0.0072	0.0072
Schistosoma mansoni	biogenic amine receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	neuropeptides capa receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	opsin-like receptor	0.0171	0.0072	0.0115
Brugia malayi	G protein-coupled receptor F59B2.13	0.0171	0.0072	0.0115
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0171	0.0072	0.0115
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0171	0.0072	0.0115
Echinococcus granulosus	neuropeptide FF receptor 2	0.0171	0.0072	0.0072
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Echinococcus granulosus	biogenic amine 5HT receptor	0.0171	0.0072	0.0072
Brugia malayi	Melatonin receptor type 1A	0.0171	0.0072	0.0115
Loa Loa (eye worm)	pax transcription factor protein 2	0.0291	0.0189	0.0304
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	neuropeptide F-like receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	g protein coupled receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0171	0.0072	0.0115
Plasmodium falciparum	glycylpeptide N-tetradecanoyltransferase	0.6421	0.6222	0.5
Schistosoma mansoni	apoptosis regulator bax	0.1829	0.1703	0.2737
Echinococcus granulosus	geminin	0.0174	0.0074	0.0074
Brugia malayi	Furin-like cysteine rich region family protein	0.021	0.011	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Echinococcus granulosus	serotonin receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	glycylpeptide N tetradecanoyltransferase	0.6421	0.6222	0.6222
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	hypothetical protein	0.0174	0.0074	0.0119
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	N-myristoyltransferase	0.6421	0.6222	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	neuropeptides capa receptor	0.0171	0.0072	0.0072
Brugia malayi	N-myristoyltransferase 2	0.6421	0.6222	1
Echinococcus multilocularis	g protein coupled receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	TYRA-2 protein	0.0171	0.0072	0.0115
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0171	0.0072	0.0115
Brugia malayi	Dopamine receptor protein 2	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Plasmodium vivax	glycylpeptide N-tetradecanoyltransferase, putative	0.6421	0.6222	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Trypanosoma brucei	N-myristoyl transferase, putative	0.6421	0.6222	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0171	0.0072	0.0115
Echinococcus granulosus	glycylpeptide N tetradecanoyltransferase	0.6421	0.6222	0.6222
Schistosoma mansoni	neuropeptide receptor	0.0171	0.0072	0.0115
Loa Loa (eye worm)	TK/EGFR protein kinase	0.021	0.011	0.0177
Echinococcus multilocularis	serotonin receptor	0.0171	0.0072	0.0072
Schistosoma mansoni	neuropeptide receptor	0.0171	0.0072	0.0115
Echinococcus granulosus	7TM GPCR rhodopsin	0.0171	0.0072	0.0072
Brugia malayi	RE15519p	0.0171	0.0072	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Schistosoma mansoni	tyrosine kinase	0.021	0.011	0.0177
Schistosoma mansoni	biogenic amine receptor	0.0171	0.0072	0.0115
Echinococcus granulosus	neuropeptide s receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	neuropeptide receptor A26	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.1829	0.1703	0.2737
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0171	0.0072	0.0115
Echinococcus granulosus	epidermal growth factor receptor	0.0113	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	hypothetical protein	0.1829	0.1703	0.2737
Echinococcus granulosus	g protein coupled receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	tm gpcr rhodopsin	0.0171	0.0072	0.0072
Echinococcus granulosus	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus granulosus	neuropeptide Y receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	somatostatin receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0171	0.0072	0.0072
Echinococcus granulosus	allatostatin A receptor	0.0171	0.0072	0.0072
Giardia lamblia	CDC72	0.6421	0.6222	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	neuropeptide F receptor	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	amine GPCR	0.0171	0.0072	0.0115
Echinococcus multilocularis	neuropeptide Y receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0171	0.0072	0.0072
Echinococcus granulosus	epidermal growth factor receptor	0.021	0.011	0.011
Echinococcus granulosus	orexin receptor type 2	0.0171	0.0072	0.0072
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0171	0.0072	0.0072
Schistosoma mansoni	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus granulosus	neuropeptide receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	g protein coupled receptor	0.0171	0.0072	0.0072
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Trichomonas vaginalis	N-myristoyl transferase, putative	0.6421	0.6222	1
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.1829	0.1703	0.2737
Brugia malayi	G protein-coupled receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0171	0.0072	0.0072
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	amine GPCR	0.0171	0.0072	0.0115
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0171	0.0072	0.0072
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	amine GPCR	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	geminin	0.0174	0.0074	0.0074
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0171	0.0072	0.0072
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Trypanosoma cruzi	N-myristoyl transferase, putative	0.6421	0.6222	0.5
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Schistosoma mansoni	tyrosine kinase	0.0112	0.0013	0.0021
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0171	0.0072	0.0072
Echinococcus granulosus	g-protein coupled receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Brugia malayi	neuropeptide F receptor	0.0171	0.0072	0.0115
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus granulosus	dro:myosuppressin receptor	0.0171	0.0072	0.0072
Schistosoma mansoni	neuropeptide receptor	0.0171	0.0072	0.0115
Schistosoma mansoni	amine GPCR	0.0171	0.0072	0.0115
Brugia malayi	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Brugia malayi	Pax transcription factor protein 2	0.0291	0.0189	0.0304
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0171	0.0072	0.0115
Echinococcus granulosus	G protein coupled receptor 139	0.0171	0.0072	0.0072
Echinococcus granulosus	g protein coupled receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	fmrfamide receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115
Echinococcus multilocularis	neuropeptide receptor	0.0171	0.0072	0.0072
Echinococcus multilocularis	neuropeptide receptor	0.0171	0.0072	0.0072
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0171	0.0072	0.0115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0171	0.0072	0.0072
Echinococcus granulosus	neuropeptide receptor	0.0171	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0072	0.0115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2137385

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1710498