Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypoxia-induced factor 1 | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | PAS domain containing protein | 0.0059 | 0.2155 | 0.2155 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2909 | 0.2909 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.2552 | 0.2552 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3255 | 0.3255 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.2552 | 0.5257 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.2552 | 0.7792 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0072 | 0.2909 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2552 | 0.2552 |
Mycobacterium ulcerans | putative regulatory protein | 0.0043 | 0.129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2552 | 0.2552 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.2552 | 0.7792 |
Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.129 | 0.129 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.2552 | 0.7792 |
Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.9134 | 0.9134 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.2552 | 0.2552 |
Onchocerca volvulus | 0.0078 | 0.3255 | 1 | |
Brugia malayi | SWIRM domain containing protein | 0.0078 | 0.3255 | 0.3255 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0072 | 0.2909 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.2552 | 0.7792 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.9134 | 0.9134 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.2552 | 0.7792 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2909 | 0.2909 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.2552 | 0.7792 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0072 | 0.2909 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.2552 | 0.2552 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.2552 | 0.2552 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2.46 uM | Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay | ChEMBL. | 22172704 |
EC50 (binding) | = 3.45 uM | Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis | ChEMBL. | 22172704 |
EC50 (binding) | = 4.74 uM | Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubation by luciferase reporter gene assay | ChEMBL. | 22172704 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.