Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | plasmepsin I | 0.0087 | 0.2502 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0087 | 0.2502 | 0.5 |
Brugia malayi | Poly | 0.0237 | 0.912 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.3317 | 0.3208 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0105 | 0.3317 | 0.3208 |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0237 | 0.912 | 1 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0237 | 0.912 | 1 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0237 | 0.912 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0237 | 0.912 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0087 | 0.2502 | 0.2744 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1096 | 0.0553 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.0237 | 0.912 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0575 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.2502 | 0.2744 |
Plasmodium falciparum | plasmepsin IV | 0.0087 | 0.2502 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0087 | 0.2502 | 0.2045 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1096 | 0.1202 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0257 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1096 | 0.1202 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0237 | 0.912 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0087 | 0.2502 | 0.2744 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1096 | 0.0553 |
Plasmodium falciparum | plasmepsin VI | 0.0087 | 0.2502 | 1 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0237 | 0.912 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1096 | 0.0553 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0087 | 0.2502 | 0.2744 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0237 | 0.912 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0087 | 0.2502 | 0.2255 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1096 | 0.061 |
Plasmodium falciparum | plasmepsin II | 0.0087 | 0.2502 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1096 | 0.061 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1096 | 0.061 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0237 | 0.912 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0087 | 0.2502 | 1 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0105 | 0.3317 | 0.3636 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1096 | 0.061 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0087 | 0.2502 | 0.2255 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0237 | 0.912 | 0.9067 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0087 | 0.2502 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.