Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cuticular endochitinase | 0.0089 | 0.2004 | 0.2004 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0141 | 1 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0099 | 0.3645 | 0.2052 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0076 | 0 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0099 | 0.3645 | 0.2052 |
Entamoeba histolytica | chitinase, putative | 0.0089 | 0.2004 | 0.5 |
Brugia malayi | Endochitinase | 0.0099 | 0.3645 | 0.2052 |
Plasmodium falciparum | conserved protein, unknown function | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0141 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible chitinase | 0.0076 | 0 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 1 | 0.5 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Loa Loa (eye worm) | microfilarial chitinase | 0.0086 | 0.1641 | 0.1641 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0099 | 0.3645 | 0.2052 |
Toxoplasma gondii | hypothetical protein | 0.0141 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0141 | 1 | 0.5 |
Brugia malayi | endochitinase | 0.0099 | 0.3645 | 0.2052 |
Leishmania major | chitinase | 0.0089 | 0.2004 | 0.5 |
Loa Loa (eye worm) | chitinase I | 0.0089 | 0.2004 | 0.2004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.