Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0185 | 0.0521 | 0.0521 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2169 | 1 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.2169 | 1 | 1 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0077 | 0 | 0.5 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0263 | 0.0893 | 0.0893 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0263 | 0.0893 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0263 | 0.0893 | 0.0893 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.2169 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1543 | 0.7007 | 0.7007 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.2169 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.023 | 0.0732 | 0.0732 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.2169 | 1 | 1 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0263 | 0.0893 | 0.0893 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0263 | 0.0893 | 0.0893 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0263 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | glutamate receptor | 0.0121 | 0.0212 | 0.0212 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.2169 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2169 | 1 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0263 | 0.0893 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.2169 | 1 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0121 | 0.0212 | 0.0212 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.023 | 0.0732 | 0.0732 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2169 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0263 | 0.0893 | 0.5 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0263 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0263 | 0.0893 | 0.0893 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2169 | 1 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2169 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2169 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.0893 | 0.0893 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0263 | 0.0893 | 0.5 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0263 | 0.0893 | 0.0893 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0121 | 0.0212 | 0.0212 |
Schistosoma mansoni | unc-13 (munc13) | 0.0263 | 0.0893 | 0.0893 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0263 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0121 | 0.0212 | 0.0212 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.2169 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0263 | 0.0893 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.2169 | 1 | 0.5 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0077 | 0 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2169 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0185 | 0.0521 | 0.0521 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.2169 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0263 | 0.0893 | 0.0893 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2169 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0121 | 0.0212 | 0.0212 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0263 | 0.0893 | 0.0893 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0263 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.0732 | 0.0732 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.2169 | 1 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.2169 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.023 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0212 | 0.0212 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.45 nM | Binding affinity to human thrombin. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.