TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 513.581 | Formula: C27H48IN
H donors: 0 H acceptors: 0 LogP: 10.18 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCc1ccc(cc1)[C@@H]1CC[C@H](CC1)[N+](CCC)(C)C.[I-]
InChi: 1S/C27H48N.HI/c1-5-7-8-9-10-11-12-13-14-24-15-17-25(18-16-24)26-19-21-27(22-20-26)28(3,4)23-6-2;/h15-18,26-27H,5-14,19-23H2,1-4H3;1H/q+1;/p-1/t26-,27-;
InChiKey: KFHXSDQSKZULMX-VZUNXAKGSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0109	0.1119	0.1051
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Trypanosoma brucei	protein kinase, putative	0.0057	0.0086	1
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	receptor protein kinase, putative	0.0057	0.0075	0.0075
Brugia malayi	map kinase activated protein kinase protein 2	0.021	0.3147	1
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.021	0.3147	0.3095
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	ankyrin repeat protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	STE family protein kinase	0.0057	0.0075	0.5
Mycobacterium tuberculosis	Conserved protein	0.0554	1	1
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0109	0.1119	0.1119
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0057	0.0075	0.5
Onchocerca volvulus		0.0109	0.1119	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	receptor protein kinase, putative	0.0057	0.0075	0.0075
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.021	0.3147	0.3095
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0075	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Echinococcus multilocularis	tyrosine protein kinase shark	0.0109	0.1119	0.1051
Onchocerca volvulus		0.0109	0.1119	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Brugia malayi	Tyrosine-protein kinase abl-1	0.0109	0.1119	0.3396
Brugia malayi	SH2 domain containing protein	0.0109	0.1119	0.3396
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0057	0.0075	0.0075
Schistosoma mansoni	protein kinase	0.0057	0.0086	0.0011
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Entamoeba histolytica	cysteine surface protein, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Echinococcus granulosus	c src tyrosine kinase	0.0109	0.1119	0.1051
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Entamoeba histolytica	serine/threonine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0057	0.0086	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0057	0.0075	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0057	0.0075	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0109	0.1119	0.1051
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0109	0.1119	0.1051
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0057	0.0086	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0109	0.1119	0.1051
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0109	0.1119	0.1051
Entamoeba histolytica	serine/threonine kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0109	0.1129	0.1062
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus multilocularis	tyrosine kinase	0.0109	0.1119	0.1051
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Schistosoma mansoni	tyrosine kinase	0.0109	0.1119	0.1051
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Leishmania major	protein kinase, putative	0.0057	0.0086	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0057	0.0075	0.0075
Echinococcus granulosus	tyrosine protein kinase shark	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Giardia lamblia	Kinase	0.0057	0.0075	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0109	0.1119	0.1051
Schistosoma mansoni	sphingosine kinase A B	0.0554	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0109	0.1119	0.1051
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Echinococcus granulosus	tyrosine protein kinase Srms	0.0109	0.1119	0.1051
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0109	0.1119	0.1051
Schistosoma mansoni	sphingoid long chain base kinase	0.0554	1	1
Brugia malayi	protein-tyrosine kinase	0.0109	0.1119	0.3396
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Onchocerca volvulus		0.0109	0.1119	1
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Onchocerca volvulus		0.0109	0.1119	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Loa Loa (eye worm)	SRC-1	0.0109	0.1119	0.1051
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0057	0.0086	1
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0057	0.0075	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0057	0.0075	0.5
Brugia malayi	Protein kinase domain containing protein	0.0109	0.1119	0.3396
Echinococcus multilocularis	sphingosine kinase 1	0.0554	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Brugia malayi	Protein kinase domain containing protein	0.0109	0.1119	0.3396
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	hypothetical protein, conserved	0.0057	0.0075	0.0075
Entamoeba histolytica	serine/threonine kinase, putative	0.0057	0.0075	0.0075
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0109	0.1119	0.1051
Entamoeba histolytica	hypothetical protein, conserved	0.0554	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0109	0.1119	0.1051
Giardia lamblia	Kinase, NEK	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0109	0.1119	0.1051
Echinococcus granulosus	tyrosine kinase	0.0109	0.1119	0.1051
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0109	0.1119	0.1051
Brugia malayi	Protein kinase domain containing protein	0.0109	0.1119	0.3396
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.021	0.3147	0.3095
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0109	0.1119	0.1051
Schistosoma mansoni	tyrosine kinase	0.0109	0.1119	0.1051
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TK family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Mycobacterium ulcerans	hypothetical protein	0.0554	1	0.5
Echinococcus multilocularis	activin receptor type	0.0057	0.0086	0.0011
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Echinococcus multilocularis	c src tyrosine kinase	0.0109	0.1119	0.1051
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0057	0.0075	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0109	0.1119	0.1051
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	serine/threonine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Onchocerca volvulus		0.0109	0.1119	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Schistosoma mansoni	tyrosine kinase	0.0109	0.1119	0.1051
Echinococcus granulosus	tyrosine kinase	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0057	0.0075	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0109	0.1119	0.1051
Schistosoma mansoni	protein kinase	0.0057	0.0086	0.0011
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Schistosoma mansoni	tyrosine kinase	0.0109	0.1119	0.1051
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0075	0.5
Brugia malayi	SH2 domain containing protein	0.0109	0.1119	0.3396
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0057	0.0086	1
Brugia malayi	Protein kinase domain containing protein	0.0109	0.1119	0.3396
Brugia malayi	SRC-1	0.0109	0.1119	0.3396
Plasmodium falciparum	protein kinase, putative	0.0057	0.0086	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Entamoeba histolytica	tyrosin kinase, putative	0.0057	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1119	0.1051
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0554	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0109	0.1119	0.1051
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0109	0.1119	0.1051
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	ankyrin repeat protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Loa Loa (eye worm)	TK/ABL protein kinase	0.0109	0.1119	0.1051
Plasmodium vivax	protein kinase, putative	0.0057	0.0075	0.5
Echinococcus granulosus	tyrosine protein kinase Blk	0.0109	0.1119	0.1051
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0057	0.0086	0.0011
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	serine/threonine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0086	0.0086
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Onchocerca volvulus		0.0109	0.1119	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0057	0.0086	0.0011
Entamoeba histolytica	tyrosin kinase, putative	0.0057	0.0075	0.0075
Schistosoma mansoni	tyrosine kinase	0.0109	0.1119	0.1051
Entamoeba histolytica	protein kinase, putative	0.0057	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0109	0.1119	0.3396
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	tyrosine kinase, putative	0.0057	0.0075	0.0075
Schistosoma mansoni	protein kinase	0.0057	0.0086	0.0011
Loa Loa (eye worm)	TK protein kinase	0.0109	0.1119	0.1051
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Schistosoma mansoni	serine/threonine protein kinase	0.021	0.3147	0.3095
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Entamoeba histolytica	hypothetical protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0109	0.1119	0.1051
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Echinococcus granulosus	activin receptor type	0.0057	0.0086	0.0011
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0109	0.1119	0.1051
Brugia malayi	Protein kinase domain containing protein	0.0109	0.1119	0.3396
Giardia lamblia	Protein 21.1	0.0057	0.0075	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Schistosoma mansoni	tyrosine kinase	0.0109	0.1119	0.1051
Giardia lamblia	Kinase, NEK	0.0057	0.0075	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0109	0.1119	0.1051
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0057	0.0075	0.0075
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.0075	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0075	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0057	0.0075	0.0075

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 26 %	Inhibition of recombinant SphK2 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine as substrate and [32gammaP]ATP assessed as residual activity at 10 uM by scintillation counting	ChEMBL.	22321213
Activity (binding)	= 67 %	Inhibition of recombinant SphK1 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine as substrate and [32gammaP]ATP assessed as residual activity at 10 uM by scintillation counting	ChEMBL.	22321213
Ki (binding)	= 35 uM	Inhibition of recombinant SphK1 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine as substrate and [32gammaP]ATP by scintillation counting	ChEMBL.	22321213
Ki (binding)	= 43 uM	Inhibition of recombinant SphK2 expressed in baculovirus infected Sf9 cells using D-erythro-sphingosine as substrate and [32gammaP]ATP by scintillation counting	ChEMBL.	22321213

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2158694

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1714735