Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.7497 | 0 | 0.5 |
Schistosoma mansoni | inositol transporter | 2.9379 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 2.9379 | 1 | 1 |
Onchocerca volvulus | 0.7497 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.7497 | 0 | 0.5 |
Schistosoma mansoni | inositol transporter | 2.9379 | 1 | 1 |
Echinococcus granulosus | solute carrier family 5 | 2.9379 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 2.9379 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 2.9379 | 1 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.7497 | 0 | 0.5 |
Brugia malayi | GH02984p | 0.7497 | 0 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 2.9379 | 1 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.7497 | 0 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 2.9379 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Intrinsic activity (functional) | = 48 % | Intrinsic activity of the compound was determined as the acceleration in contraction of spontaneously beating guinea pig atria relative to that induced by isoproterenol | ChEMBL. | 11714605 |
Intrinsic activity (functional) | = 70 % | Human beta-3 adrenergic receptor agonist activity by measurement of cAMP accumulation levels in CHO membranes expressing human beta-3 receptor. | ChEMBL. | 11714605 |
Intrinsic activity (functional) | = 70 % | Human beta-3 adrenergic receptor agonist activity by measurement of cAMP accumulation levels in CHO membranes expressing human beta-3 receptor. | ChEMBL. | 11714605 |
Ki (binding) | = 2800 nM | Binding affinity against CHO cells transfected with human beta-3 adrenergic receptor in the presence of [125I]-iodocyanopindolol | ChEMBL. | 11714605 |
Ki (binding) | = 2800 nM | Binding affinity against CHO cells transfected with human beta-3 adrenergic receptor in the presence of [125I]-iodocyanopindolol | ChEMBL. | 11714605 |
Selectivity (binding) | = 2 | Selectivity as the ratio of Ki of beta-2 adrenergic receptor to the Ki of beta-3 adrenergic receptor. | ChEMBL. | 11714605 |
Selectivity (binding) | = 3 | Selectivity measured as the ratio of Ki of Beta-1 Adrenergic receptor to the Ki of Beta-3 Adrenergic receptor | ChEMBL. | 11714605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.