Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 28.33 nM | Inverse agonist activity at human CB2 receptor expressed in CHO cells assessed as increase in forskolin-induced cAMP accumulation incubated for 45 mins by TR-FRET method based LANCE cAMP assay | ChEMBL. | 23072339 |
Ki (binding) | = 7.657577 | Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells incubated for 1 hr | ChEMBL. | 23072339 |
Ki (binding) | = 22 nM | Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells incubated for 1 hr | ChEMBL. | 23072339 |
Ki (binding) | > 20000 nM | Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cells incubated for 1 hr | ChEMBL. | 23072339 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.