Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0338 | 0.121 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1318 | 0.912 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0297 | 0.088 | 0.1122 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0971 | 0.6319 | 0.6319 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0565 | 0.3042 | 0.3335 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0971 | 0.6319 | 0.6929 |
Loa Loa (eye worm) | glutamate receptor | 0.0456 | 0.2162 | 0.2162 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0338 | 0.121 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0297 | 0.088 | 0.088 |
Loa Loa (eye worm) | glutamate receptor | 0.1159 | 0.7838 | 0.7838 |
Loa Loa (eye worm) | hypothetical protein | 0.1427 | 1 | 1 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0297 | 0.088 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.088 | 0.088 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0188 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0971 | 0.6319 | 0.6319 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1427 | 1 | 1 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0188 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0565 | 0.3042 | 0.3881 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1159 | 0.7838 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.105 | 0.6958 | 0.8878 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.3 uM | Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assay | ChEMBL. | 23088558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.